Mechanisms of histamine release from isolated mast cell granules by calcium with phosphatidyl serine

Histamine is released from isolated mast cell granules with intact membranes by calcium (10 mM) in presence of phosphatidyl serine (25–50 μg/ml). The release occurs both in Krebs-Ringer solution and in sucrose solution without monovalent cations, but the release in Krebs-Ringer solution is somewhat higher. The histamine release is associated with increased… CONTINUE READING