Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications.

@article{Allen2005MechanismsOH,
  title={Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications.},
  author={David A Allen and Muhammad Magdi Yaqoob and Steven M. Harwood},
  journal={The Journal of nutritional biochemistry},
  year={2005},
  volume={16 12},
  pages={705-13}
}
Cellular responses to high glucose are numerous and varied but ultimately result in functional changes and, often, cell death. High glucose induces oxidative and nitrosative stress in many cell types causing the generation of species such as superoxide, nitric oxide and peroxynitrite and their derivatives. The role of these species in high glucose-mediated… CONTINUE READING