Mechanisms of high-density lipoprotein reduction after probucol treatment: changes in plasma cholesterol esterification/transfer and lipase activities.

@article{Chiesa1993MechanismsOH,
  title={Mechanisms of high-density lipoprotein reduction after probucol treatment: changes in plasma cholesterol esterification/transfer and lipase activities.},
  author={Giulia Chiesa and Stefano Michelagnoli and M Cassinotti and Gemma Gianfranceschi and Jos{\'e} Pablo Werba and Franco Pazzucconi and Cesare R. Sirtori and Guido Franceschini},
  journal={Metabolism: clinical and experimental},
  year={1993},
  volume={42 2},
  pages={
          229-35
        }
}
Probucol treatment results in a significant reduction of plasma high-density lipoprotein (HDL) levels. Since the remodeling of HDL within the plasma compartment is a crucial determinant of HDL levels, the activities of several factors participating in the process, ie, lecithin:cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), and lipoprotein and hepatic lipases (LPL, HL), were evaluated in 15 hypercholesterolemic patients treated with probucol (1 g/d) for 8 weeks… CONTINUE READING

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