Mechanisms of hepatotoxicity.

  title={Mechanisms of hepatotoxicity.},
  author={Hartmut Jaeschke and Gregory J. Gores and Arthur I. Cederbaum and Jack A. Hinson and Dominique Pessayre and John J. Lemasters},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={65 2},
  • H. JaeschkeG. Gores J. Lemasters
  • Published 1 February 2002
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
This review addresses recent advances in specific mechanisms of hepatotoxicity. Because of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important target of the toxicity of drugs, xenobiotics, and oxidative stress. In cholestatic disease, endogenously generated bile acids produce hepatocellular apoptosis by stimulating Fas translocation from the cytoplasm to the plasma membrane where self-aggregation occurs to trigger apoptosis. Kupffer cell activation… 

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