Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

  title={Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease},
  author={Yuki Kawano and David M. Cohen},
  booktitle={Journal of Gastroenterology},
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation in the absence of excess alcohol intake. NAFLD is the most common chronic liver disease, and ongoing research efforts are focused on understanding the underlying pathobiology of hepatic steatosis with the anticipation that these efforts will identify novel therapeutic targets. Under physiological conditions, the low steady-state triglyceride concentrations in the liver are attributable to a precise balance… CONTINUE READING
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