Mechanisms of hair cell death and protection.

  title={Mechanisms of hair cell death and protection.},
  author={Alan G Cheng and Lisa L Cunningham and Edwin W. Rubel},
  journal={Current opinion in otolaryngology & head and neck surgery},
  volume={13 6},
PURPOSE OF REVIEW Sensory hair cells are mechanotransducers of the inner ear that are essential for hearing and balance. Hair cell death commonly occurs following acoustic trauma or exposure to ototoxins, such as the aminoglycoside antibiotics and the antineoplastic agent cisplatin. Loss of these inner ear sensory cells can lead to permanent sensorineural hearing loss, balance disturbance, or both. Currently, the only effective clinical intervention is prevention from exposure to known ototoxic… CONTINUE READING


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