Mechanisms of gonadotropin-releasing hormone agonist action in the human male.

@article{Bhasin1986MechanismsOG,
  title={Mechanisms of gonadotropin-releasing hormone agonist action in the human male.},
  author={Shalender Bhasin and Ronald S. Swerdloff},
  journal={Endocrine reviews},
  year={1986},
  volume={7 1},
  pages={106-14}
}
Agonist analogs of GnRH are being increasingly utilized to induce medical castration for treatment of a variety of hormonally responsive clinical disorders. However, the mechanism/s of their paradoxical antigonadal action in the human male remain poorly understood. Basal and integrated concentrations of immunoreactive LH after intermediate term (4-16 weeks) GnRH agonist treatment are only modestly decreased and cannot fully account for the far greater decline in serum testosterone (T… CONTINUE READING

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