Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic release.

@article{Parpura2004MechanismsOG,
  title={Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic release.},
  author={Vladimir Parpura and Eliana Scemes and David Conover Spray},
  journal={Neurochemistry international},
  year={2004},
  volume={45 2-3},
  pages={259-64}
}
Neuronal exocytotic release of glutamate at synapses involves a highly specialized vesicular apparatus, consisting of a variety of proteins connected to the vesicles or required for vesicular fusion to the presynaptic membrane. Astrocytes also release glutamate, and recent evidence indicates that this release can modify neuronal function. Several mechanisms have been proposed for astrocytic release of glutamate under pathological conditions, such as reversal of glutamate transporters and… CONTINUE READING
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