Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.

@article{Raiteri2007MechanismsOG,
  title={Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.},
  author={Luca Raiteri and Simona Zappettini and Marco Milanese and Ernesto Fedele and Maurizio Raiteri and Giambattista Bonanno},
  journal={Journal of neurochemistry},
  year={2007},
  volume={103 3},
  pages={952-61}
}
Extracellular [K+] can increase during some pathological conditions, resulting into excessive glutamate release through multiple mechanisms. We here investigate the overflow of [3H]D-aspartate ([3H] D-ASP) and of endogenous glutamate elicited by increasing [K+] from purified rat cerebrocortical synaptosomes. Depolarization with [K+] <or= 15 mmol/L provoked [3H] D-ASP and glutamate overflows almost totally dependent on external Ca2+. Consistent with release by exocytosis, the overflow of [3H] D… CONTINUE READING

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