Mechanisms of glucose intolerance in cystic fibrosis.

  title={Mechanisms of glucose intolerance in cystic fibrosis.},
  author={Kamlesh Mohan and Helen Miller and Paula Dyce and Ruth Grainger and Ruth Hughes and Jiten Vora and Martin James Ledson and Martin John Walshaw},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  volume={26 6},
AIMS Although cystic fibrosis-related diabetes (CFRD), a poor prognostic factor in cystic fibrosis (CF), is characterized by insulinopenia, the role of insulin resistance is unclear. Using a prospective study design, we measured insulin resistance, pancreatic beta-cell function and correlated glycaemic status with clinical parameters. METHODS Oral glucose tolerance test was performed in 60 stable adult CF patients. Insulin sensitivity and beta-cell function were measured using the homeostatic… CONTINUE READING
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