Mechanisms of glucocorticoid induced osteoporosis

  title={Mechanisms of glucocorticoid induced osteoporosis},
  author={Ernesto Canalis},
  booktitle={Current opinion in rheumatology},
Glucocorticoids modify osteoblastic cell differentiation, number, and function. Glucocorticoids stimulate osteoclastogenesis and increase the expression of receptor activator of Nuclear factor-kappaB ligand and colony-stimulating factor-1, and decrease the expression of osteoprotegerin. However, the most significant effect of glucocorticoids in bone is an inhibition of bone formation. This inhibition is caused by a decrease in the number of osteoblasts secondary to a shift in the… CONTINUE READING

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