Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia.

@article{Bolli1984MechanismsOG,
  title={Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia.},
  author={Geremia B Bolli and Pierpaolo De Feo and Gabriele Perriello and Salvatore De Cosmo and Pietro Compagnucci and Fausto Santeusanio and Paolo Brunetti and Roger H. Unger},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={73 4},
  pages={917-22}
}
To elucidate the mechanisms controlling the response of glucagon to hypoglycemia, a vital component of the counterregulatory hormonal response, the role of intraislet insulin was studied in seven normal subjects and five subjects with insulin-dependent diabetes mellitus (IDDM) (of less than 15-mo duration). In the normal subjects, hypoglycemia (arterial plasma glucose [PG] 53 +/- 3 mg/dl) induced by an intravenous insulin infusion (30 mU/m2 X min for 1 h, free immunoreactive insulin [FIRI] 58… CONTINUE READING

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The physiology of glucagon.

Journal of diabetes science and technology • 2010

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