Mechanisms of genome instability in Hutchinson-Gilford progeria


Hutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disorder. It arises from a single point mutation in the LMNA gene. This mutation stimulates an aberrant splicing event and produces progerin, an isoform of the lamin A protein. Accumulation of progerin disrupts numerous physiological pathways and induces defects in nuclear… (More)
DOI: 10.1007/s11515-016-1435-x


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@article{Zhang2016MechanismsOG, title={Mechanisms of genome instability in Hutchinson-Gilford progeria}, author={H Zhang and Kan Cao}, journal={Frontiers in Biology}, year={2016}, volume={12}, pages={49-62} }