Mechanisms of generation of local ΔpH in mitochondria and bacteria

@article{Medvedev2014MechanismsOG,
  title={Mechanisms of generation of local ΔpH in mitochondria and bacteria},
  author={Emile S Medvedev and Alexei A. Stuchebrukhov},
  journal={Biochemistry (Moscow)},
  year={2014},
  volume={79},
  pages={425-434}
}
The concepts of global and local coupling between proton generators, the enzymes of the respiratory chain, and the consumer, the ATP synthase, coexist in the theory of oxidative phosphorylation. Global coupling is trivial proton transport via the aqueous medium, whereas local coupling implies that the protons pumped are consumed before they escape to the bulk phase. In this work, the conditions for the occurrence of local coupling are explored. It is supposed that the membrane retains protons… CONTINUE READING
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