Mechanisms of general anesthesia.

  title={Mechanisms of general anesthesia.},
  author={Beverley A. Orser and Kevin J Canning and John F. MacDonald},
  journal={Current opinion in anaesthesiology},
  volume={15 4},
PURPOSE OF REVIEW Anesthetics influence a wide variety of transmitter- and voltage-gated ion channels in the mammalian central nervous system. At the molecular level, the gamma-aminobutyric acid (GABA) subtype A receptor has emerged as a primary therapeutic target. This review highlights recent advances in our understanding of how anesthetics modify GABA(A) receptor function. RECENT FINDINGS Anesthetics bind to discrete selective binding sites on GABA(A) receptors--a discovery that challenges… CONTINUE READING