Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides

@article{Simes1999MechanismsOG,
  title={Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides},
  author={S{\'e}rgio Sim{\~o}es and Vladimir Slepushkin and Pedro Francisco Bussad Pires and Rezső G{\'a}sp{\'a}r and Montenegro de Lima and Nejat D{\"u}zg{\"u}neş},
  journal={Gene Therapy},
  year={1999},
  volume={6},
  pages={1798-1807}
}
Association of a targeting ligand such as transferrin, or an endosome disrupting peptide such as GALA, with cationic liposome–DNA complexes (‘lipoplexes’) results in a significant enhancement of transfection of several cell types (Simões S et al, Gene Therapy 1998; 5: 955–964). Although these strategies can overcome some of the barriers to gene delivery by lipoplexes, the mechanisms by which they actually enhance tranfection is not known. In studies designed to establish the targeting… CONTINUE READING
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Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

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