Mechanisms of gas-exchange impairment in idiopathic pulmonary fibrosis.

@article{Agust1991MechanismsOG,
  title={Mechanisms of gas-exchange impairment in idiopathic pulmonary fibrosis.},
  author={Alvar Agust{\'i} and Josep Roca and Joaquim Gea and Peter D. Wagner and Antoni Xaubet and Roberto Rodr{\'i}guez-Rois{\'i}n},
  journal={The American review of respiratory disease},
  year={1991},
  volume={143 2},
  pages={219-25}
}
To investigate the mechanisms of pulmonary gas-exchange impairment in idiopathic pulmonary fibrosis (IPF) and to evaluate their potential relationship to the CO diffusing capacity (DLCO), we studied 15 patients with IPF (mean DLCO, 52% of predicted) at rest (breathing room air and pure O2) and during exercise. We measured pulmonary hemodynamics and respiratory gas-exchange variables, and we separated the ventilation-perfusion (VAQ) mismatching and O2 diffusion limitation components of arterial… CONTINUE READING

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