Mechanisms of gap junction traffic in health and disease.

@article{Hesketh2009MechanismsOG,
  title={Mechanisms of gap junction traffic in health and disease.},
  author={Geoffrey G. Hesketh and Jennifer E. van Eyk and Gordon F. Tomaselli},
  journal={Journal of cardiovascular pharmacology},
  year={2009},
  volume={54 4},
  pages={263-72}
}
Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A prominent feature of acquired structural heart disease is remodeling of GJ protein expression and localization concomitant with increased susceptibility to lethal arrhythmias, leading many to hypothesize that the two are causally linked. Detailed understanding of the cellular mechanisms that… CONTINUE READING

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