Mechanisms of foxp3+ T regulatory cell-mediated suppression.

@article{Shevach2009MechanismsOF,
  title={Mechanisms of foxp3+ T regulatory cell-mediated suppression.},
  author={Ethan M Shevach},
  journal={Immunity},
  year={2009},
  volume={30 5},
  pages={636-45}
}
Foxp3(+) T regulatory (Treg) cells control all aspects of the immune response. Here, I will review the in vitro model systems that have been developed to define the mechanisms used by Treg cells to suppress a large number of distinct target cell types. These mechanisms can be broadly divided into those that target T cells (suppressor cytokines, IL-2 consumption, cytolysis) and those that primarily target antigen-presenting cells (decreased costimulation or decreased antigen presentation… CONTINUE READING
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