Mechanisms of focal calcification in rabbit aortas: role of calcifying vesicles.

@article{Hsu2006MechanismsOF,
  title={Mechanisms of focal calcification in rabbit aortas: role of calcifying vesicles.},
  author={Howard H. T. Hsu and Ossama Tawfik},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2006},
  volume={54 7},
  pages={402-11}
}
BACKGROUND We previously demonstrated that calcification in rabbit thoracic aortas is initiated in the lower zone of the extensively thickened plaques (LZP) adjacent to the media. Whether osteogenesis or a local increase in calcifying vesicles underlies the focal calcification remains to be established. METHODS To determine that focal calcification is related to osteogenesis, an obligatory osteogenic biomarker, alkaline phosphatase (ALP) activity, was evaluated in the unfixed thoracic aorta… CONTINUE READING