Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections.

@article{Tejedor2003MechanismsOF,
  title={Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections.},
  author={Mar{\'i}a Teresa Tejedor and Jos{\'e} Luis Mart{\'i}n and Margarita Mar{\'i}a Navia and Joan Freixes and Jordi Vil{\`a}},
  journal={Veterinary microbiology},
  year={2003},
  volume={94 4},
  pages={295-301}
}
Chronic otitis externa in dogs is often associated with Pseudomonas aeruginosa infection. Fluoroquinolones are often used for treating such infections. Fluoroquinolone resistance mechanisms were characterized in 10 strains of P. aeruginosa isolated from chronic canine otitis externa. Nine out of ten strains harbored a mutation in the gyrA gene and presented an overexpression of efflux pump(s). There was a good correlation between the lipophilicity of the fluoroquinolone being tested and the… CONTINUE READING

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