Mechanisms of fluid secretion by polycystic epithelia.

  title={Mechanisms of fluid secretion by polycystic epithelia.},
  author={Lawrence P. Sullivan and J. J. Grantham},
  journal={Kidney international},
  volume={49 6},
We have sought to determine the mechanisms driving fluid secretion by the cystic epithelium in autosomal dominant polycystic kidney disease (ADPKD). We have performed in vitro experiments on intact cysts dissected from discarded ADPKD kidneys, on monolayers of cells cultured from the cystic epithelium and on microcysts clonally derived from single cultured cells. These preparations absorb fluid in the control state but secrete fluid in response to native cyst fluid, to adenylate cyclase… CONTINUE READING