Mechanisms of fiber-induced diseases: implications for the safety evaluation of synthetic vitreous fibers.

@article{Everitt1994MechanismsOF,
  title={Mechanisms of fiber-induced diseases: implications for the safety evaluation of synthetic vitreous fibers.},
  author={Jeffrey I Everitt},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1994},
  volume={20 3 Pt 2},
  pages={S68-75}
}
Inhalation of certain natural mineral fibers, such as amphibole asbestos, is associated with the development of inflammatory, fibroproliferative, and neoplastic diseases in the lung and pleura of man and experimental animals. The mechanisms by which fibers induce fibrosis and cancer are largely unknown, but are thought to be modulated by reactive oxygen species and altered growth factor pathways. Studies in rats using intracavitary implantation and instillation of fiber preparations led to the… CONTINUE READING