Mechanisms of fever production and lysis: lessons from experimental LPS fever.

@article{Roth2014MechanismsOF,
  title={Mechanisms of fever production and lysis: lessons from experimental LPS fever.},
  author={Joachim Roth and Clark M. Blatteis},
  journal={Comprehensive Physiology},
  year={2014},
  volume={4 4},
  pages={1563-604}
}
Fever is a cardinal symptom of infectious or inflammatory insults, but it can also arise from noninfectious causes. The fever-inducing agent that has been used most frequently in experimental studies designed to characterize the physiological, immunological and neuroendocrine processes and to identify the neuronal circuits that underlie the manifestation of the febrile response is lipopolysaccharide (LPS). Our knowledge of the mechanisms of fever production and lysis is largely based on this… CONTINUE READING

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