Corpus ID: 28181358

Mechanisms of fever in humans

  title={Mechanisms of fever in humans},
  author={Philip Ifesinachi},
This review examines the mechanisms of fever in humans. Persistent fever that cannot be explained after repeated routine clinical inquiries is called fever of unknown origin. Fever may be provoked by many stimuli. Most often, they are protozoans, bacteria and their endotoxins, viruses, yeasts, spirochets, immune reactions, several hormones, medications, and synthetic polynucleotides. These substances are commonly called exogenic pyrogens. Cells stimulated by exogenic pyrogens centrally affect… Expand
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Antiinflammatory , analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera
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The concept of sickness behavior: a brief chronological account of four key discoveries.
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  • Biology, Medicine
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Results from several key studies showed that: (1) sickness behavior is a motivational state; (2) sicknessbehavior is a well-organized adaptive response to infection; (3) cytokines produced by activated leukocytes induce sickness behavior; and (4) cytokine transmit messages from the periphery to the brain using humoral and neural pathways. Expand
Fever in the critically ill medical patient
It is controversial whether most medical patients with moderate degrees of fever should be treated with antipyretic or direct cooling therapies, although treatment of fever may improve patient comfort and reduce metabolic demand. Expand
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Current parental attitudes toward fever are explored, to compare these attitudes with those described by Schmitt in 1980, and to determine whether recent, more aggressive laboratory testing and presumptive treatment for occult bacteremia is associated with increased parental concern regarding fever. Expand
Fever: Fact and fiction.
This review, using evidence from the literature, attempts to clarify such diverse issues as the concept of normal body temperature, the investigation and rationale for the treatment of postoperative fever, the beneficial effects of fever and the potential adverse effects of suppressing fever. Expand
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Hyperpyrexia in the emergency department.
A case is presented and the features of the differential diagnoses and management of the hyperpyrexic patient are reviewed and the correct diagnosis is established. Expand
Hypothermia therapy after traumatic brain injury in children.
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Temperature management in acute neurologic disorders.
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Normal oral, rectal, tympanic and axillary body temperature in adult men and women: a systematic literature review.
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Harrison’s Principles of Internal Medicine