Mechanisms of ferroptosis

  title={Mechanisms of ferroptosis},
  author={Jennifer Yinuo Cao and Scott J. Dixon},
  booktitle={Cellular and Molecular Life Sciences},
Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma membrane polyunsaturated fatty acids. Cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression may be sensitized to this process… CONTINUE READING