95 Citations
Mechanisms underlying development of visual maps and receptive fields.
- BiologyAnnual review of neuroscience
- 2008
A major goal now is to determine how axon guidance cues and a growing list of other molecules cooperate with spontaneous and visually evoked activity to give rise to the circuits underlying precise receptive field tuning and orderly visual maps.
Visual System Development in
- Biology
- 2013
The cellular, molecular and inductive mechanisms that sculpt each of these key developmental processes essential for normal visual system development are beginning to be understood.
Visual System Development in Vertebrates
- Biology
- 2013
Activity-dependent mechanisms drive the formation of eye-specific layering of synaptic inputs in visual targets, and gradients of signalling molecules, together with spontaneous neural activity, drive a point-to-point mapping of retinal axons invisual targets, ensuring accurate reconstruction of the visual image.
Milestones and mechanisms for generating specific synaptic connections between the eyes and the brain.
- BiologyCurrent topics in developmental biology
- 2010
Refinement of the retinogeniculate pathway
- BiologyThe Journal of physiology
- 2008
The major changes in connectivity that occur in this mouse species and a potential mechanism that can account for such remodelling are outlined.
Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening.
- BiologyJournal of neurophysiology
- 2012
It is suggested that binocular competition prior to eye opening enhances retinocollicular synaptic strength and the morphological development of retino-recipient neurons and contrast with the predictions of a constrained-connectivity model of binocular map development.
From Retinal Waves to Activity-Dependent Retinogeniculate Map Development
- BiologyPloS one
- 2012
A neural model is described of how spontaneous retinal waves are formed in infant mammals, and how these waves organize activity-dependent development of a topographic map in the lateral geniculate nucleus, with connections from each eye segregated into separate anatomical layers to provide a foundation for analyzing the temporal dynamics whereby the visual cortex itself develops.
Wiring visual systems: common and divergent mechanisms and principles
- BiologyCurrent Opinion in Neurobiology
- 2017
References
SHOWING 1-10 OF 57 REFERENCES
Development of ocular dominance columns in the absence of retinal input
- BiologyNature Neuroscience
- 1999
It is proposed that formation of ocular dominance columns relies on molecular cues present on thalamic axons, cortical cells or both, and the patterning of geniculocortical afferents resists this dramatic change in the level, source and pattern of spontaneous activity.
An Instructive Role for Retinal Waves in the Development of Retinogeniculate Connectivity
- BiologyNeuron
- 2002
Eye-Specific Retinogeniculate Segregation Independent of Normal Neuronal Activity
- BiologyScience
- 2003
The segregation of initially intermingled left and right eye inputs to the dorsal lateral geniculate nucleus (DLGN) during development is thought to be in response to precise spatial and temporal…
Spontaneous Retinal Activity Mediates Development of Ocular Dominance Columns and Binocular Receptive Fields in V1
- BiologyNeuron
- 2006
Emergence of order in visual system development.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1996
Observations suggest that a neural circuit within the immature retina is responsible for generating specific spatiotemporal patterns of neural activity, and that nerve cell function is essential for correct wiring of the visual system during early development.
Competition in retinogeniculate patterning driven by spontaneous activity.
- BiologyScience
- 1998
Interocular competition driven by endogenous retinal activity determines the pattern of eye-specific connections from retina to LGN, demonstrating that spontaneous activity can produce highly stereotyped patterns of connections before the onset of visual experience.
Necessity for afferent activity to maintain eye-specific segregation in ferret lateral geniculate nucleus.
- BiologyScience
- 2000
Results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes.
Early development of ocular dominance columns.
- BiologyScience
- 2000
It is proposed that ocular dominance column formation relies on the targeting of distinct axonal populations to defined locales in cortical layer 4.
Role of Subplate Neurons in Functional Maturation of Visual Cortical Columns
- BiologyScience
- 2003
When subplate neurons are ablated, ocular dominance columns do not form in the visual cortex despite the robust presence of thalamic axons in layer 4, and it is shown that subplate ablation also prevents formation of orientation columns.