Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.

@article{Biegel2001MechanismsOE,
  title={Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.},
  author={Lisa B. Biegel and Mark E. Hurtt and S. Randall Frame and John C O'Connor and Jon C. Cook},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={60 1},
  pages={
          44-55
        }
}
  • L. Biegel, M. Hurtt, J. Cook
  • Published 1 March 2001
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Wyeth-14,643 (WY) and ammonium perfluorooctanoate (C8) belong to a diverse class of compounds which have been shown to produce hepatic peroxisome proliferation in rodents. From previous work, WY, but not C8, has been shown to produce hepatocellular carcinoma in rats, while C8 has been shown to produce Leydig cell adenomas. In addition, based on a review of bioassay data a relationship appears to exist between peroxisome-proliferating compounds and Leydig cell adenoma and pancreatic acinar cell… 
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  • 2004
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PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
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An in-depth analysis of the state of the science on several topics critical to evaluating the relationship between the MOA for PPARα agonists and the human relevance of related animal tumors produces a range of outcomes, depending partly on the quality and quantity of MOA data available from laboratory animals and related information from human data sources.
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