Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD.

@article{Guenette2014MechanismsOE,
  title={Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD.},
  author={Jordan A. Guenette and Roberto C. Chin and Sicheng Cheng and Paolo B Dominelli and Natya Raghavan and Katherine Alexandra Webb and J. Alberto Neder and Denis O'donnell},
  journal={The European respiratory journal},
  year={2014},
  volume={44 5},
  pages={1177-87}
}
The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative sensory consequences. Subjects meeting spirometric criteria for mild COPD (n=16) and age and sex-matched controls (n=16) underwent detailed pulmonary function testing and a symptom limited cycle… CONTINUE READING
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