Mechanisms of ethanol-drug-nutrition interactions.

  title={Mechanisms of ethanol-drug-nutrition interactions.},
  author={Charles S. Lieber},
  journal={Journal of toxicology. Clinical toxicology},
  volume={32 6},
Mechanisms of the toxicologic manifestations of ethanol abuse are reviewed. Hepatotoxicity of ethanol results from alcohol dehydrogenase-mediated excessive hepatic generation of nicotinamide adenine dinucleotide and acetaldehyde. It is now recognized that acetaldehyde is also produced by an accessory (but inducible) pathway, the microsomal ethanol-oxidizing system, which involves a specific cytochrome P450. It generates oxygen radicals and activates many xenobiotics to toxic metabolites… CONTINUE READING