Mechanisms of establishment of persistent SARS-CoV-infected cells.

  title={Mechanisms of establishment of persistent SARS-CoV-infected cells.},
  author={Tetsuya Mizutani and Shuetsu Fukushi and Koji Ishii and Yuko Sasaki and Tsuyoshi Kenri and Masayuki Saijo and Yumi Kanaji and Kinji Shirota and Ichiro Kurane and Shigeru Morikawa},
  journal={Biochemical and biophysical research communications},
  volume={347 1},
Previously, we reported the establishment of cells with persistent SARS-CoV infection after apoptotic events and showed that both JNK and PI3K/Akt signaling pathways are important for persistence by treatment with inhibitors at the early stages of SARS-CoV infection. However, the mechanisms of establishment of persistent infection are still unclear. In this study, we investigated which signaling pathways play important roles in escape from apoptosis in cells infected with SARS-CoV. In… CONTINUE READING

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