Mechanisms of epithelial barrier impairment in HIV infection.

  title={Mechanisms of epithelial barrier impairment in HIV infection.},
  author={Martin Stockmann and Heinz Schmitz and Michael Fromm and Wolfgang Schmidt and Georg Pauli and Peter Scholz and E. O. Riecken and J{\"o}rg-Dieter Schulzke},
  journal={Annals of the New York Academy of Sciences},
Diarrhea and malabsorption due to intestinal dysfunction are common symptoms in HIV infection. The pathophysiologic mechanisms of these alterations are often not known, and the role of HIV per se is still controversially discussed. We measured the epithelial transport and barrier function by means of a miniaturized Ussing chamber system in the duodenum of HIV-infected patients in different disease stages, determined by the CD4 cell count in the serum as well as symptoms in patients with and… CONTINUE READING