Mechanisms of epinephrine-induced glucose intolerance in normal humans.

  title={Mechanisms of epinephrine-induced glucose intolerance in normal humans.},
  author={Luigi Sacc{\'a} and Carlo Vigorito and Michele Cicala and Biagio Ungaro and Robert S. Sherwin},
  journal={The Journal of clinical investigation},
  volume={69 2},
To evaluate the role of the splanchnic bed in epinephrine-induced glucose intolerance, we selectively assessed the components of net splanchnic glucose balance, i.e., splanchnic glucose uptake and hepatic glucose production, and peripheral glucose uptake by combining infusion of [3-(3)H]glucose with hepatic vein catheterization. Normal humans received a 90-min infusion of either glucose alone (6.5 mg/kg(-1) per min(-1)) or epinephrine plus glucose at two dose levels: (a) in amounts that… CONTINUE READING


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