Mechanisms of endothelin-1-induced MAP kinase activation in adrenal glomerulosa cells

@article{Shah2006MechanismsOE,
  title={Mechanisms of endothelin-1-induced MAP kinase activation in adrenal glomerulosa cells},
  author={Bukhtiar H. Shah and Albert J. Baukal and Hong-bing Chen and Ali Baqadar Shah and KevinJ. Catt},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2006},
  volume={102},
  pages={79-88}
}
G protein-coupled receptors (GPCRs) such as angiotensin II, bradykinin and endothelin-1 (ET-1) are critically involved in the regulation of adrenal function, including aldosterone production from zona glomerulosa cells. Whereas, substantial data are available on the signaling mechanisms of ET-1 in cardiovascular tissues, such information in adrenal glomerulosa cells is lacking. Bovine adrenal glomerulosa (BAG) cells express receptors for endothelin-1 (ET-1) and their stimulation caused… CONTINUE READING
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