Mechanisms of endonuclease-mediated mRNA decay.

@article{Schoenberg2011MechanismsOE,
  title={Mechanisms of endonuclease-mediated mRNA decay.},
  author={Daniel R Schoenberg},
  journal={Wiley interdisciplinary reviews. RNA},
  year={2011},
  volume={2 4},
  pages={
          582-600
        }
}
Endonuclease cleavage was one of the first identified mechanisms of mRNA decay but until recently it was thought to play a minor role to the better-known processes of deadenylation, decapping, and exonuclease-catalyzed decay. Most of the early examples of endonuclease decay came from studies of a particular mRNA whose turnover changed in response to hormone, cytokine, developmental, or nutritional stimuli. Only a few of these examples of endonuclease-mediated mRNA decay progressed to the point… CONTINUE READING
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