Mechanisms of endonuclease-mediated mRNA decay.

  title={Mechanisms of endonuclease-mediated mRNA decay.},
  author={Daniel R Schoenberg},
  journal={Wiley interdisciplinary reviews. RNA},
  volume={2 4},
Endonuclease cleavage was one of the first identified mechanisms of mRNA decay but until recently it was thought to play a minor role to the better-known processes of deadenylation, decapping, and exonuclease-catalyzed decay. Most of the early examples of endonuclease decay came from studies of a particular mRNA whose turnover changed in response to hormone, cytokine, developmental, or nutritional stimuli. Only a few of these examples of endonuclease-mediated mRNA decay progressed to the point… CONTINUE READING

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