Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice.

@article{Choudhury2004MechanismsOE,
  title={Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice.},
  author={Sharmila Choudhury and Michael Wilson and M. E. Goddard and Kieran O'Dea and Masao Takata},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 5},
  pages={L902-10}
}
Polymorphonuclear leukocytes (PMN) play an important role in ventilator-induced lung injury (VILI), but the mechanisms of pulmonary PMN recruitment, particularly early intravascular PMN sequestration during VILI, have not been elucidated. We investigated the physiological and molecular mechanisms of pulmonary PMN sequestration in an in vivo mouse model of VILI. Anesthetized C57/BL6 mice were ventilated for 1 h with high tidal volume (injurious ventilation), low tidal volume and high positive… CONTINUE READING

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