Mechanisms of drug resistance in Mycobacterium tuberculosis.

  title={Mechanisms of drug resistance in Mycobacterium tuberculosis.},
  author={Mary Margaret Wade and Ying Zhang},
  journal={Frontiers in bioscience : a journal and virtual library},
  • M. WadeYing Zhang
  • Published 1 November 2009
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
Tuberculosis is a worldwide health problem posing increasing threat with the spread of HIV infection and drug resistant Mycobacterium tuberculosis strains. Consequently, control of this disease has become a significant challenge despite the availability of chemotherapy and BCG vaccine. Drug resistance for all first-line anti-tuberculosis agents and some second-line agents has been observed. Moreover, the occurrence of strains of M. tuberculosis resistant to multiple anti-tuberculosis drugs is… 

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