Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.

@article{Buxbaum1992MechanismsOD,
  title={Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.},
  author={Joel N Buxbaum},
  journal={Hematology/oncology clinics of North America},
  year={1992},
  volume={6 2},
  pages={323-46}
}
  • Joel N Buxbaum
  • Published 1992 in Hematology/oncology clinics of North America
All forms of MIDD are related to the presence of an expanded clone of B-cell origin that is producing an Ig product, usually, but not exclusively an L-chain, which is predisposed to deposit in tissues, with or without some degree of processing. The nature of the processing is currently unclear, although limited proteolysis is likely to play a major role in most, but not all, patients. Diagnosis is made by the identification, using immunohistochemical techniques, of the monoclonal Ig nature of… CONTINUE READING

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