Mechanisms of daptomycin resistance in Staphylococcus aureus.

  title={Mechanisms of daptomycin resistance in Staphylococcus aureus.},
  author={Glenn W Kaatz and Tammy S Lundstrom and Susan M. Seo},
  journal={International journal of antimicrobial agents},
  volume={28 4},
Daptomycin resistance in Staphylococcus aureus emerged during therapy of tricuspid endocarditis. Susceptibility to daptomycin of the parent strain (SA-675), other daptomycin-susceptible strains and the non-susceptible mutant (SA-684) was heterogeneous; however, subpopulations growing at concentrations above the minimum inhibitory concentration (MIC) were not stably resistant. Stable resistance was produced only by serial passage on daptomycin-containing media. Daptomycin dissipated the membrane… CONTINUE READING

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