[Mechanisms of cytostasis and metastasis].

Abstract

TGFbeta signaling controls a plethora of cellular responses in human development and disease. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGFbeta receptors, the receptor-mediated activation of Smad transcription factors, the Smad-mediated regulation of target gene expression, and the negative control of the cell cycle by these signals. Loss of TGFbeta cytostatic responsiveness and gain of metastastic activity are common alterations of this pathway in cancer. The analysis of these normal and altered states is providing new insights into physiology, pathology and therapy.

Cite this paper

@article{Sol2004MechanismsOC, title={[Mechanisms of cytostasis and metastasis].}, author={Joan Massagu{\'e} Sol{\'e}}, journal={Anales de la Real Academia Nacional de Medicina}, year={2004}, volume={121 4}, pages={559-71} }