Mechanisms of cytosolic Ca2+ suppression by prostaglandin E2 receptors in rat melanotrophs.

@article{Nagata2003MechanismsOC,
  title={Mechanisms of cytosolic Ca2+ suppression by prostaglandin E2 receptors in rat melanotrophs.},
  author={Tetsuji Nagata and Nobuya Harayama and Nobuyuki Sasaki and Madoka Inoue and Ken-ichi Tanaka and Yumiko Toyohira and Yasuhito Uezono and Takashi Maruyama and Nobuyuki Yanagihara and Yoichi Ueta and Izumi Shibuya},
  journal={Journal of neuroendocrinology},
  year={2003},
  volume={15 1},
  pages={33-41}
}
We have previously reported that voltage-dependent Ca2+ (VDC) channels of rat melanotrophs are inhibited by prostaglandin E2 (PGE2). In this study, mechanisms involved in the inhibitory actions of PGE2 receptors of rat melanotrophs were analysed using reverse transcriptase-polymerase chain reaction (RT-PCR), Ca2+-imaging and whole-cell, patch-clamp techniques with recently developed EP agonists, each of which is selective for the known four subclasses of EP receptors (EP1-4). PGE2 reversibly… CONTINUE READING

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