Mechanisms of cytochrome c release from mitochondria

  title={Mechanisms of cytochrome c release from mitochondria},
  author={Carmen Garrido and Lorenzo Galluzzi and Mathilde Brunet and Pierre Emmanuel Puig and C{\'e}line Didelot and Guido Kroemer},
  journal={Cell Death and Differentiation},
In healthy cells, cytochrome c (Cyt c) is located in the mitochondrial intermembrane/intercristae spaces, where it functions as an electron shuttle in the respiratory chain and interacts with cardiolipin (CL). Several proapoptotic stimuli induce the permeabilization of the outer membrane, facilitate the communication between intermembrane and intercristae spaces and promote the mobilization of Cyt c from CL, allowing for Cyt c release. In the cytosol, Cyt c mediates the allosteric activation of… CONTINUE READING
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