Mechanisms of cytochrome P450 substrate oxidation: MiniReview.

  title={Mechanisms of cytochrome P450 substrate oxidation: MiniReview.},
  author={F Peter Guengerich},
  journal={Journal of biochemical and molecular toxicology},
  volume={21 4},
Cytochrome P450 (P450) enzymes catalyze a variety of oxidation and some reduction reactions, collectively involving thousands of substrates. A general chemical mechanism can be used to rationalize most of the oxidations and involves a perfenyl intermediate (FeO3+) and odd-electron chemistry, i.e. abstraction of a hydrogen atom or electron followed by oxygen rebound and sometimes rearrangement. This general mechanism can explain carbon hydroxylation, heteroatom oxygenation and dealkylation… CONTINUE READING

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