Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.

@article{Werry2002MechanismsOC,
  title={Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.},
  author={Tim D. Werry and Graeme Wilkinson and Gary B. Willars},
  journal={Neuro-Signals},
  year={2002},
  volume={11 1},
  pages={45-57}
}
Alteration in [Ca(2+)](i) (the intracellular concentration of Ca(2+)) is a key regulator of many cellular processes. To allow precise regulation of [Ca(2+)](i) and a diversity of signalling by this ion, cells possess many mechanisms by which they are able to control [Ca(2+)](i) both globally and at the subcellular level. Among these are many members of the superfamily of GPCRs (G-protein-coupled receptors), which are characterized by the presence of seven transmembrane domains. Typically, those… CONTINUE READING