Mechanisms of cooperativity underlying sequence-independent β-sheet formation

@article{Guo2002MechanismsOC,
  title={Mechanisms of cooperativity underlying sequence-independent $\beta$-sheet formation},
  author={Chinlin Guo and Herbert Levine and Margaret S. Cheung and David A. Kessler},
  journal={Journal of Chemical Physics},
  year={2002},
  volume={116},
  pages={4353-4365}
}
We investigate the formation of β-sheet structures in proteins without sequence-dependent side-chain interactions. To accomplish this, we introduce a model which explicitly incorporates both solvation effects and the angular dependence (on the protein backbone) of hydrogen bond formation. The thermodynamics of this model is studied by exploring the density of states for the entire system and the local couplings in a partially folded structure. Our results suggest that solvation dynamics… 

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