Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations.

Abstract

BACKGROUND The tyrosine kinase Janus kinase 2 (JAK2) is important in triggering nuclear translocation and regulation of target genes expression through signal transducer and activator of transcription pathways. The valine-to-phenylalanine mutation at amino acid 617 (V617F), which results in the deregulation of JAK2, has been implicated in the oncogenesis of… (More)
DOI: 10.1002/cncr.24183

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Cite this paper

@article{Lee2009MechanismsOC, title={Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations.}, author={Tai-Sung Lee and Wanlong Ma and Xi Zhang and Francis Joseph Giles and Hagop M. Kantarjian and Maher Albitar}, journal={Cancer}, year={2009}, volume={115 8}, pages={1692-700} }