Mechanisms of compound I formation in heme peroxidases.

  title={Mechanisms of compound I formation in heme peroxidases.},
  author={Alexander N. P. Hiner and Emma L Raven and Roger N. F. Thorneley and Francisco Garc{\'i}a-C{\'a}novas and Jos{\'e} Neptuno Rodr{\'i}guez-L{\'o}pez},
  journal={Journal of inorganic biochemistry},
  volume={91 1},
The formation of compound I is the first step in the reaction mechanism of plant heme peroxidases. This intermediate stores two oxidizing equivalents from hydrogen peroxide as an oxyferryl iron center and a radical, either on the porphyrin ring or on a tryptophan residue. Site-directed mutagenesis has proved to be a most useful tool for the identification of the intermediates involved and the resulting nature of the compound I formed. Although there is no doubt that an acid-base mechanism… CONTINUE READING
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