Mechanisms of clinically relevant drug interactions associated with tacrolimus.

  title={Mechanisms of clinically relevant drug interactions associated with tacrolimus.},
  author={Uwe Christians and Wolfgang Jacobsen and Leslie Z Benet and A. Lampen},
  journal={Clinical pharmacokinetics},
  volume={41 11},
The clinical management of tacrolimus, a macrolide used as immunosuppressant after transplantation, is complicated by its narrow therapeutic index in combination with inter- and intraindividually variable pharmacokinetics. As a substrate of cytochrome P450 (CYP) 3A enzymes and P-glycoprotein, tacrolimus interacts with several other drugs used in transplantation medicine, which also are known CYP3A and/or P-glycoprotein inhibitors and/or inducers. In clinical studies, CYP3A/P-glycoprotein… CONTINUE READING


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