Mechanisms of cisplatin-induced ototoxicity and prevention

@article{Rybak2007MechanismsOC,
  title={Mechanisms of cisplatin-induced ototoxicity and prevention},
  author={Leonard P Rybak and Craig A. Whitworth and Debashree Mukherjea and Vickram Ramkumar},
  journal={Hearing Research},
  year={2007},
  volume={226},
  pages={157-167}
}
Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies.
  • Qing Tang, Xianren Wang, Z. Zou
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2021
Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity
TLDR
There is an urgent need to discover safe and effective protective agents that do not interfere with the efficacy of cisplatin against tumors yet preserve hearing, and a number of potential therapeutic targets that can be addressed to provide hearing protection.
Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies
TLDR
Clinical and experimental studies of cisplatin ototoxicity are summarized, and understanding its toxicity mechanisms, clinical repercussions and prevention strategies are focused on.
Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models
TLDR
The aim of the present review is to analyze the role of ROS in the mechanisms causing cisplatin-mediated apoptosis in the inner ear and the contribution of the different pathways involved, emphasizing the main strategies to blockade events leading to apoptosis of cochlear cells.
Mechanisms of cisplatin ototoxicity and progress in otoprotection
  • L. Rybak
  • Biology
    Current opinion in otolaryngology & head and neck surgery
  • 2007
TLDR
This review presents exciting new data published in the past year that help to elucidate the mechanisms of cisplatin ototoxicity and could lead to important clinical trials to determine whether the findings in experimental animals can translate into effective treatments to prevent cisPlatin ottoxicity.
In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCk3
TLDR
The hypothesis that pre-treatment with Ginkgo biloba extract is able to protect OCk3 against cisplatin induced toxicity in a mouse inner ear cell line (OCk3) is supported.
CYTOTOXIC AND MOLECULAR MECHANISMS IN OTOTOXICITY OF CISPLATIN
TLDR
Studies of compounds to prevent ototoxicity may provide compounds for use in routine clinical practice and prevent one of the major dose-limiting side effects of cisplatin therapy, which will increase treatment efficacy and improve patient quality of life.
Cisplatin ototoxicity and protection: clinical and experimental studies.
TLDR
Recent important clinical and experimental investigations of cisplatin ototoxicity are summarized and the utility of protective agents employed in patients and in experimental animals is discussed.
Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity
TLDR
Alpha-lipoic acid contributes to protecting mitochondrial function by preventing ROS accumulation and inhibiting apoptotic cell death and post-treatment with ALA consistently showed an almost equal restorative effect to pretreatment, in vitro and in vivo, supporting the possible use of ALA as a therapeutic agent for cisplatin-induced ototoxicity.
...
...

References

SHOWING 1-10 OF 83 REFERENCES
Ototoxicity: therapeutic opportunities.
Mechanism of cisplatin ototoxicity: antioxidant system.
TLDR
Cisplatin ototoxicity was evidenced as elevated hearing thresholds and prolonged wave I latencies in response to various stimuli on ABRs, and superoxide dismutase, catalase activities and malondialdehyde levels were significantly increased in the cochleae of cisplatin injected rats.
Effect of protective agents against cisplatin ototoxicity.
TLDR
The results suggest the possibility that the clinical use of protective agents could effectively reduce or prevent damage to the inner ear of patients receiving cisplatin chemotherapy, provided that the antitumor effect is not altered.
Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity.
  • L. Muldoon, M. Pagel, E. Neuwelt
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
TLDR
Delayed administration of sodium thiosulfate (STS) may provide a mechanism to reduce the ototoxicity caused by administration of carboplatin or cisplatin for both central nervous system and systemic cancer chemotherapy.
SEVERE NEUROTOXICITY, OTOTOXICITY AND NEPHROTOXICITY FOLLOWING HIGH-DOSE CISPLATIN AND AMIFOSTINE
TLDR
A case of severe toxicity with cisplatin is reported in a girl with epithelial cell carcinoma of the ovary despite the use of amifostine, a broad-spectrum cytoprotector of normal tissues, according to the authors.
...
...