Mechanisms of cisplatin-induced ototoxicity and prevention

@article{Rybak2007MechanismsOC,
  title={Mechanisms of cisplatin-induced ototoxicity and prevention},
  author={L. Rybak and C. Whitworth and D. Mukherjea and V. Ramkumar},
  journal={Hearing Research},
  year={2007},
  volume={226},
  pages={157-167}
}
  • L. Rybak, C. Whitworth, +1 author V. Ramkumar
  • Published 2007
  • Biology, Medicine
  • Hearing Research
  • Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately, ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In animal studies and in human temporal bone investigations, several areas of the cochlea are damaged, including outer hair cells in the basal turn, spiral ganglion cells and the stria vascularis, resulting in hearing impairment. The mechanisms appear to involve the production of reactive oxygen species (ROS), which… CONTINUE READING
    381 Citations

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The proposal of this study was to evaluate in human beings, using distortion product otoacoustic emission (DPOAE) test, the action of ginkgo biloba extract (GBE761)as a possible… Expand
    ConditionsHearing Loss, Ototoxicity
    InterventionDrug
    Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity
    Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies
    • 47
    • Highly Influenced
    • PDF
    Cisplatin-induced ototoxicity: Transporters playing a role in cisplatin toxicity
    • 48
    • Highly Influenced
    Mechanisms of cisplatin ototoxicity and progress in otoprotection
    • L. Rybak
    • Medicine
    • Current opinion in otolaryngology & head and neck surgery
    • 2007
    • 175
    In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCk3
    • 8
    • Highly Influenced
    Cisplatin ototoxicity and protection: clinical and experimental studies.
    • 238
    Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells
    • 7
    • PDF
    A Review of Cisplatin-Associated Ototoxicity.
    • 6

    References

    SHOWING 1-10 OF 83 REFERENCES
    Ototoxicity: therapeutic opportunities.
    • 247
    Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS.
    • 47
    Mechanism of cisplatin ototoxicity: antioxidant system.
    • 296
    Effect of protective agents against cisplatin ototoxicity.
    • 183
    Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity.
    • L. Muldoon, M. Pagel, +5 authors E. Neuwelt
    • Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2000
    • 110
    • PDF