Mechanisms of cisplatin-induced ototoxicity and prevention
@article{Rybak2007MechanismsOC, title={Mechanisms of cisplatin-induced ototoxicity and prevention}, author={Leonard P Rybak and Craig A. Whitworth and Debashree Mukherjea and Vickram Ramkumar}, journal={Hearing Research}, year={2007}, volume={226}, pages={157-167} }
453 Citations
Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies.
- BiologyEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- 2021
Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity
- BiologyExpert opinion on drug metabolism & toxicology
- 2020
There is an urgent need to discover safe and effective protective agents that do not interfere with the efficacy of cisplatin against tumors yet preserve hearing, and a number of potential therapeutic targets that can be addressed to provide hearing protection.
Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies
- BiologyToxics
- 2015
Clinical and experimental studies of cisplatin ototoxicity are summarized, and understanding its toxicity mechanisms, clinical repercussions and prevention strategies are focused on.
Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models
- BiologyEuropean Archives of Oto-Rhino-Laryngology
- 2012
The aim of the present review is to analyze the role of ROS in the mechanisms causing cisplatin-mediated apoptosis in the inner ear and the contribution of the different pathways involved, emphasizing the main strategies to blockade events leading to apoptosis of cochlear cells.
Cisplatin-induced ototoxicity: Transporters playing a role in cisplatin toxicity
- BiologyHearing Research
- 2013
Mechanisms of cisplatin ototoxicity and progress in otoprotection
- BiologyCurrent opinion in otolaryngology & head and neck surgery
- 2007
This review presents exciting new data published in the past year that help to elucidate the mechanisms of cisplatin ototoxicity and could lead to important clinical trials to determine whether the findings in experimental animals can translate into effective treatments to prevent cisPlatin ottoxicity.
In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCk3
- Biology
- 2008
The hypothesis that pre-treatment with Ginkgo biloba extract is able to protect OCk3 against cisplatin induced toxicity in a mouse inner ear cell line (OCk3) is supported.
Cisplatin ototoxicity and protection: clinical and experimental studies.
- BiologyThe Tohoku journal of experimental medicine
- 2009
Recent important clinical and experimental investigations of cisplatin ototoxicity are summarized and the utility of protective agents employed in patients and in experimental animals is discussed.
Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity
- BiologyCell Death & Disease
- 2018
Alpha-lipoic acid contributes to protecting mitochondrial function by preventing ROS accumulation and inhibiting apoptotic cell death and post-treatment with ALA consistently showed an almost equal restorative effect to pretreatment, in vitro and in vivo, supporting the possible use of ALA as a therapeutic agent for cisplatin-induced ototoxicity.
A Review of Cisplatin-Associated Ototoxicity.
- MedicineSeminars in hearing
- 2019
The importance of a team-based approach to complement an audiological monitoring program in reducing any further loss in the quality of life of affected patients is highlighted, as there is currently no otoprotective agent routinely recommended for the prevention of cisplatin-associated ototoxicity.
References
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Cisplatin ototoxicity was evidenced as elevated hearing thresholds and prolonged wave I latencies in response to various stimuli on ABRs, and superoxide dismutase, catalase activities and malondialdehyde levels were significantly increased in the cochleae of cisplatin injected rats.
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Delayed administration of sodium thiosulfate (STS) may provide a mechanism to reduce the ototoxicity caused by administration of carboplatin or cisplatin for both central nervous system and systemic cancer chemotherapy.
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