Mechanisms of cisplatin-induced ototoxicity and prevention

@article{Rybak2007MechanismsOC,
  title={Mechanisms of cisplatin-induced ototoxicity and prevention},
  author={L. Rybak and C. Whitworth and D. Mukherjea and V. Ramkumar},
  journal={Hearing Research},
  year={2007},
  volume={226},
  pages={157-167}
}
  • L. Rybak, C. Whitworth, +1 author V. Ramkumar
  • Published 2007
  • Biology, Medicine
  • Hearing Research
    • Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately, ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In animal studies and in human temporal bone investigations, several areas of the cochlea are damaged, including outer hair cells in the basal turn, spiral ganglion cells and the stria vascularis, resulting in hearing impairment. The mechanisms appear to involve the production of reactive oxygen species (ROS), which… CONTINUE READING
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    381 Citations
    Highly Influencial Citations
    21
    Background Citations
    168
    Methods Citations
    1
    Results Citations
    5

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans
    The proposal of this study was to evaluate in human beings, using distortion product otoacoustic emission (DPOAE) test, the action of ginkgo biloba extract (GBE761)as a possible… Expand
    ConditionsHearing Loss, Ototoxicity
    InterventionDrug
    University of Brasilia
    June 2007 - June 2008
    381 Citations
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