Mechanisms of cisplatin-induced ototoxicity and prevention

  title={Mechanisms of cisplatin-induced ototoxicity and prevention},
  author={L. Rybak and C. Whitworth and D. Mukherjea and V. Ramkumar},
  journal={Hearing Research},
  • L. Rybak, C. Whitworth, +1 author V. Ramkumar
  • Published 2007
  • Biology, Medicine
  • Hearing Research
  • Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately, ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In animal studies and in human temporal bone investigations, several areas of the cochlea are damaged, including outer hair cells in the basal turn, spiral ganglion cells and the stria vascularis, resulting in hearing impairment. The mechanisms appear to involve the production of reactive oxygen species (ROS), which… CONTINUE READING
    381 Citations

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