Mechanisms of ciliogenesis suppression in dividing cells

@inproceedings{Goto2016MechanismsOC,
  title={Mechanisms of ciliogenesis suppression in dividing cells},
  author={Hidemasa Goto and Hironori Inaba and Masaki Inagaki},
  booktitle={Cellular and Molecular Life Sciences},
  year={2016}
}
The primary cilium is a non-motile and microtubule-enriched protrusion ensheathed by plasma membrane. Primary cilia function as mechano/chemosensors and signaling hubs and their disorders predispose to a wide spectrum of human diseases. Most types of cells assemble their primary cilia in response to cellular quiescence, whereas they start to retract the primary cilia upon cell-cycle reentry. The retardation of ciliary resorption process has been shown to delay cell-cycle progression to the S or… CONTINUE READING